Adolescent E-Cigarette Users’ Perceptions of the Harm and Addictiveness of Conventional Cigarette Smoking

As the popularity of e-cigarettes continues to rise and their link with conventional cigarette smoking becomes clearer, it is important to understand how e-cigarette users compare with non-users, conventional cigarette smokers, and dual users on perceptions of addiction risk of conventional cigarette smoking as well as on other risk factors associated with smoking. PRC graduate student trainee Olusegun Owotomo, PRC faculty research associate Julie Maslowsky, and co-author Alexandra Loukas found that adolescent e-cigarette users endorsed a number of attitudes, perceptions, and characteristics that are risk factors for conventional cigarette smoking. These perceptions may leave them vulnerable to becoming conventional cigarette smokers or dual users in the future and potentially increase their risk for nicotine addiction.Population Research Cente

The magnificent “I” in business education: Evidence from Greece

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.The goal of this research study has been twofold. First, to examine the level of narcissism and its individual traits in students who study business, in the particular context of a regional country such as Greece and second, to test how several demographic variables are related to narcissism levels. The study consists of a theoretical part on narcissism in business education and an empirical part that was based on a survey conducted with the use of a questionnaire. The analysis includes hypothesis testing and basic statistical tests. Findings suggest that sex, study levels, years of business experience and (personal/family) income do impact specific narcissistic dimensions, which may be cause for concern both for employers and higher education providers. The study was conducted in a regional country, the participants were students of public higher education institutions only, and the questionnaire was self-reported, and this could lead to likely social desirability effects. The investigation of narcissism in the Greek business education might be of interest to: (a) business education providers (for providing curriculum that help future managers/leaders to deploy the positive characteristics of narcissism and avoid or not to develop the negative ones) and (b) to future employers to apply more effective human resource practices, i.e. selection, training, rewarding. The study at hand aimed to investigate the presence of narcissism and its individual (narcissistic) behavioral dimensions in students studying business in Greece

Hispanic Parent Attitudes and Preschool Children\u27s Time with Activity-Promoting Media

Purpose: Home media that promote physical activity offer potential benefits in obesity prevention efforts for children, to the extent that they may represent “screen time” that is not sedentary. This study examined the relationships of home media density and parent media attitudes to preschool children’s time with TV, DVDs, and videogames, and children’s time with activity-promoting genres. Methods: Hispanic mothers (N=237) of children aged six to 60 months reported on their preschool-aged children’s time with television, DVD players, and videogames, and time spent using activity-promoting programs or genres. Surveys in Spanish and English assessed the number of screen media channels and activity-promoting media genres used by the children; child time with three media channels and three activity-promoting genres served as outcome measures in a structural equation model. Results: Mothers reported that children’s time with activity-promoting TV programs, DVDs and videogames was about half of the total time spent with those media channels (15-30 minutes for activity-promoting media time and 30-45 minutes for total time with TV, DVDs, and videogames). Confirmatory factor analyses established the latent variables of media density and parent media attitudes. The structural equation model reflected significant effects of parent media attitudes upon children’s total time with media and home media density upon children’s time with activity-promoting media. . Mothers’ media attitudes were not significantly related to their education, child gender, or their perception of the child as more active than other children. A re-specified model that incorporated correlations between child gender, parent education, and difficulty in setting media time limits provided an excellent fit [χ2 (33, N= 237) =36.53, p = .30, RMSEA = .02 CFI = .95, TLI = .94, WRMR =.76] of the model to the data. Conclusions: Children’s time with media may not be sedentary. Activity-promoting media offer potential benefits in obesity prevention efforts for children, to the extent that they may increase the time that children are physically active. Parent attitudes can influence preschool children’s time with media, and the density of media in the home influences children’s use of activity-promoting media

Changes in use of cigarettes and non-cigarette alternative products among college students

• E-cigarette use increased to 25% among cigarette smokers and 3% for non-smokers. • Cigarette smokers were 8.5 times more likely than non-smokers to use e-cigarettes. • Hookah use increased among non-cigarette smokers, but declined among smokers. Introduction: The present study examined change in use of various smoked and smokeless non-cigarette alternative products in a sample of college students, stratified by current, or past 30-day, cigarette smoking status. Methods: Participants were 698 students from seven four-year colleges in Texas. Participants completed two waves of online surveys regarding tobacco use, knowledge, and attitudes, with 14 months between each wave. Results: The most prevalent products used by the entire sample at Wave 1 were cigarettes, followed by hookah, cigars/cigarillos/little cigars, and electronic cigarettes (e-cigarettes). At Wave 2, prevalence of e-cigarette use surpassed use of cigars/cigarillos/little cigars. Snus and chew/snuff/dip were relatively uncommon at both waves. Examination of change in use indicated that e-cigarette use increased across time among both current cigarette smokers and non-cigarette smokers. Prevalence of current e-cigarette use doubled across the 14-month period to 25% among current smokers and tripled to 3% among non-cigarette smokers. Hookah use also increased across time, but only among non-cigarette smokers, whereas it decreased among current cigarette smokers. Use of all other non-cigarette alternatives remained unchanged across time. Logistic regression analysis was used to examine the socio-demographic predictors of Wave 2 e-cigarette use, the only product that increased in use among both current cigarette smokers and non-cigarette smokers. Results indicated that Wave 1 current cigarette use and Wave 1 current e-cigarette use, but not gender, age, or race/ethnicity, were significantly associated with Wave 2 e-cigarette use. Conclusions: Findings underscore the need to track changes in the use of non-cigarette alternatives and call for additional research examining the factors contributing to change in use. a b s t r a c t a r t i c l e i n f

Snus use and rejection in the USA

OBJECTIVE: To determine whether snus might become a strategy for reducing the harm associated with cigarette smoking in the USA as appears to be the case in Sweden, we examined receptivity to snus use in two cities with the greatest exposure to the major brands. METHODS: A dual frame, telephone survey and a brief mail survey were conducted in 2011 and 2012 in Indianapolis, Indiana and Dallas/Fort Worth Texas. Over 5000 adults completed surveys. Trial, ever use, current use and reasons for using or quitting snus after trial were measured. RESULTS: Among male smokers, 29.9% had ever tried snus (CI 22.7 to 38.1) and 4.2% were current users (CI 1.6 to 10.7). Among female smokers, 8.5% ever tried snus (CI 4.4 to 15.7) and current use was unknown. Current use was virtually absent among former smokers and never smokers. A major predictor of any level of snus use was current use of conventional smokeless tobacco. Those who tried and gave up snus cited curiosity (41.3%) and the fact that it was available at low or no cost (30%) as reasons for trial; reasons for not continuing included preferring another form of tobacco (75.1%) and disliking the mouth feel (34.6%). Almost all current snus users indicated that they were trying to cut down on cigarettes, but few (3.9%) were using it to quit smoking entirely. CONCLUSIONS: The low rate of adoption of snus suggests that neither the hopes nor the fears surrounding this new product are likely to be realised in the USA with the current marketing patterns

Parental Alcoholism and Co-Occurring Antisocial Behavior: Prospective Relationships to Externalizing Behavior Problems in their Young Sons

The hypothesis that parental alcoholism and co-occurring antisocial behavior would be indirectly linked to child externalizing behavior problems through child lack of control, current levels of parent depression, family conflict, and parent–child conflict was tested using manifest variable regression analysis. Participants were a community sample of 125 families with an alcoholic father and 83 ecologically matched but nonsubstance abusing families involved in the first 2 waves of an ongoing longitudinal study (with 3 years between each wave). All families had a biological son who was 3–5 years old at study onset. Results revealed that child lack of control mediated the relation between paternal alcoholism and the son's subsequent externalizing behavior problems. Family conflict was a significant mediator of maternal and paternal lifetime antisocial behavior effects and father–son conflict mediated paternal lifetime antisocial behavior effects. Study implications are discussed within the context of parental socialization of antisocial behavior.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44590/1/10802_2004_Article_294631.pd

Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model

<p>Abstract</p> <p>Background</p> <p>The treatment paradigm in advanced renal cell carcinoma (RCC) has changed in the recent years. Sunitinib has been established as a new standard for first-line therapy. We studied the prognostic significance of baseline characteristics and we compared the risk stratification with the established Memorial Sloan Kettering Cancer Center (MSKCC) model.</p> <p>Methods</p> <p>This is a retrospective analysis of patients treated in six Greek Oncology Units of HECOG. Inclusion criteria were: advanced renal cell carcinoma not amenable to surgery and treatment with Sunitinib. Previous cytokine therapy but no targeted agents were allowed. Overall survival (OS) was the major end point. Significance of prognostic factors was evaluated with multivariate cox regression analysis. A model was developed to stratify patients according to risk.</p> <p>Results</p> <p>One hundred and nine patients were included. Median follow up has been 15.8 months and median OS 17.1 months (95% CI: 13.7-20.6). Time from diagnosis to the start of Sunitinib (<= 12 months vs. >12 months, p = 0.001), number of metastatic sites (1 vs. >1, p = 0.003) and performance status (PS) (<= 1 vs >1, p = 0.001) were independently associated with OS. Stratification in two risk groups ("low" risk: 0 or 1 risk factors; "high" risk: 2 or 3 risk factors) resulted in distinctly different OS (median not reached [NR] vs. 10.8 [95% confidence interval (CI): 8.3-13.3], p < 0.001). The application of the MSKCC risk criteria resulted in stratification into 3 groups (low and intermediate and poor risk) with distinctly different prognosis underlying its validity. Nevertheless, MSKCC model did not show an improved prognostic performance over the model developed by this analysis.</p> <p>Conclusions</p> <p>Studies on risk stratification of patients with advanced RCC treated with targeted therapies are warranted. Our results suggest that a simpler than the MSKCC model can be developed. Such models should be further validated.</p

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.

Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain-gut interactions underlying IBS

DU Undergraduate Showcase: Research, Scholarship, and Creative Works

DU Undergraduate Showcase: Research, Scholarship, and Creative Work

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis